Cancer is now the second leading cause of death in the Caribbean. Despite this growing burden, many Caribbean small island nations have health systems that struggle to provide optimal cancer care for their populations. A recently published paper Cancer Control in the Caribbean island countries and territories: some progress but the journey continues1 co-authored by Dr. Glennis Andall-Brereton, Senior Technical Officer for Non-Communicable Diseases at CARPHA, reports “cancer causes a fifth of deaths in the Caribbean region and its incidence is increasing.” The article further states that incidence and mortality patterns of cancer in the Caribbean reflect globally widespread epidemiological transitions, and show cancer profiles that are unique to the Region. This third paper in the Lancet Series “Cancer Control in Small Island Nations In this fourth paper of the Series, Advancing cancer care and prevention in the Caribbean: a survey of strategies for the region, Dr. Andall-Brereton and others identify several promising initiatives to improve cancer prevention and treatment that have emerged across CARICOM countries. About the Lancet The Lancet, currently ranked second out of 160 journals in the Medicine, General & Internal subject category, is the world’s leading general medical journal. The papers are part of a five-part Lancet Series “Cancer Control in Small Island Nations”. This Series papers emphasise the crucial role of collaborative approaches—including through funding and investment opportunities with more developed countries—to create comprehensive cancer control programmes to improve cancer planning, prevention, and treatment in these under-resourced small island nations.